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Alkaline Phosphatase-importance in bone diseases

sources of Alkaline Phosphatase-
  • bone
  • intestine
  • liver
  • placenta
importance of alkaline phosphatase in bone disesese:
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  • Serum alkaline phosphatse is the most valuable enzyme for assessment of bone disesases and serves as index of osteoblastic activity.
  • Increased level of alkaline phosphatase are seen in-
                         a.Pagets diseases:-level of alkaline phosphatase are higher in Pagets disease than in any other condition. (excpt hereditary hypophosphatasia).
                         b.Hyperparathyroidism:-serum alkaline phosphatase may be raised depending upon degree of involvement of bone. 

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